Medicine for SCID ???

 What is SCID ?

Severe combined immunodeficiency (SCID) is an uncommon hereditary problem described by the upset advancement of useful T cells and B cells brought about by various hereditary changes that bring about varying clinical presentations.

SCID includes faulty neutraliser reaction because of either direct inclusion with B lymphocytes or through inappropriate B lymphocyte initiation because of non-useful T-partner cells.

both"arms" (B cells and T cells) of the versatile safe framework are weakened because of a deformity in one of a few potential qualities.

 SCID is the most serious type of essential immunodeficiencies and there are currently at any rate nine diverse known qualities in which transformations lead to a type of SCID.

 It is otherwise called the air pocket kid illness and air pocket child sickness since its casualties are amazingly powerless against irresistible infections and some of them, for example, David Vetter, have gotten renowned for living in a sterile climate. SCID is the consequence of a safe framework so profoundly undermined that it is considered practically missing.

So would be thinking what bio-technology has provide in return.

So for your kind information bio-tech has provided a solution that is "Gene Therapy"

I Know, I know that my audience is inquisitive in knowing everything, there are many question in your mind. We"ll go step by step:- 

 What is Gene therapy ?

Gene therapy is a collection of method that allows correction of a gene defect  that has been diagnosed in the child or embryo. Here genes are inserted into person's cell and tissue to treat the disease.

Correction of a genetic defect involves delivery of a normal gene into the individual or embryo to take over the function of and compensate for nonfunctional gene. 

Has Gene therapy been practiced ?

First Gene Therapy, The first landmark gene therapy was performed at National institute of Health (NIH),USA by W. French Anderson and Michael Blaese. 

In September 1990 they treated a 4 year old girl for inherited immunodeficiency called Severe combined immunodeficiency (SCID) also referred to as adenosine deaminase deficiency (ADA)

Method of Gene Therapy for SCID Disease ?

SCID is caused by a defect in the gene for the enzyme adenosine deaminase. The patient have SCID do not have functioning T-Lymphocytes and therefore, they cannot provide immune responses against invading pathogen.

The ideal approach is to give a patient a functioning ADA that breaks down toxic biological product.

1) A normal human gene, encoding the enzyme adenosine deaminase is introduced into retrovirus.

2) Retrovirus infects lymphocyte extracted from bone marrow of the patient and cultured 

3) Retrovirus makes a DNA copy of its RNA. This DNA carrying the normal gene inserted into chromosome of host cell.

4) These engineered cell are inserted into patients bone marrow.

5) The lymphocytes subsequently produced by these bone marrow stem cells have fully functional ADA gene. These cells can play normal role in patients immune system.