Process of production of antibiotic.

 Now as we know about the antibiotics it is important to know how they are produced. If want to know about antibiotics either visit my previous blog or click on the link :-

Antibiotics

Before understanding the concept of production of antibiotics we need to understand what does an antibiotic do.

Actions of antibiotic

Antibiotic function either as bactericides (ie killing bacteria) or       bacteriostatic. This can be done by :-

• Disruption of wall synthesis e.g. penicillin, bacitracin.

• Disruption of plasmalemma repair and synthesis e.g. polymyxin, nystatin.

• Inhibition of 50 S Ribosome function e.g. erythromycin.

WHAT IS GOOD ANTIBIOTIC ?

Good antibiotic are those antibiotics which are harmless to host having no side effect and are harmless to normal microflora of elementary canal. It has ability to destroy or kill or retard or cease pathogens as well as broad spectrum and effective against all strains of pathogens and has quick actions.

 

Production of Antibiotic

Suitable strains of micro-organism is cultivated on a sterilized medium provided with optimum pH, aeration, temperature, antifoaming agent and antibiotic agent. 

When sufficient antibiotic has diffused into a medium the micro-organism is separated and antibiotic is extracted from the medium by precipitation ,absorption or solvent treatment. It is purified, concentrated and bioassayed before packing.